个人简介

周国栋，男，山东曲阜人，聊城大学农业与生物学院专任教师，博士，讲师。2024年毕业于扬州大学兽医专业，获兽医专业博士学位，同年到聊城大学工作。主要研究方向为噬菌体制剂研发和新型细菌载体疫苗开发。在《Microbiology Spectrum》、《Frontiers in Immunology》及《Vaccine》等期刊上发表论文7篇，申请国家发明专利2项。

教学工作

研究方向

1.  噬菌体制剂的研发与推广应用

2.  新型细菌载体疫苗开发

科研项目

1. 减毒沙门菌递送猪肺炎支原体保护性抗原疫苗开发及评价（SJCX22-1804），江苏省研究生实践创新项目，2022.12-2024.06，1.5万元，主持。

2. 噬菌体诱导肠炎沙门菌EOMVs生成机制及免疫保护评估，聊城大学博士启动基金，2025.01-2027.12，20万元，主持。

代表性成果

1. Zhou G, Tian Y, Tian J, Ma Q, Huang S, Li Q, Wang S, Shi H*. Oral Immunization with attenuated Salmonella Choleraesuis expressing the P42 and P97 antigens protects mice against Mycoplasma hyopneumoniae Challenge. Microbiology Spectrum, 2022 dec 21, 10(6): e0236122.（IF: 3.7，中科院一区)

2. Zhou G, Zhao Y, Ma Q, Li Q, Wang S and Shi H*. Manipulation of host immune defenses by effector proteins delivered from multiple secretion systems of Salmonella and its application in vaccine research. Frontiers in Immunology, 2023, 14: 1152017.（IF: 7.6，中科院二区）

3. Zhou G, Tian J, Tian Y, Ma Q, Li Q, Wang S, Shi H. Recombinant-attenuated Salmonella enterica serovar Choleraesuis vector expressing the PlpE protein of Pasteurella multocida protects mice from lethal challenge. BMC Veterinary Research, 2023 Aug 19, 19(1): 128.（IF: 2.6，中科院二区）

4. Zhou G, Ma Q, Li Q, Wang S, Shi H. The disruption of LPS in Salmonella Typhimurium provides partial protection against Salmonella Choleraesuis as a live attenuated vaccine. Vaccine, 2023 Sep 22; 41(41): 5951-5956.（IF: 5.5，中科院三区）

5. Li Q, Zhou G, Fei X, Tian Y, Wang S, Shi H. Engineered Bacterial Outer Membrane Vesicles with Lipidated Heterologous Antigen as an Adjuvant-Free Vaccine Platform for Streptococcus suis. Applied and Environmental Microbiology, 2023 Mar 29; 89(3): e0204722. （IF: 4.4，中科院二区)

6. Li Q, Li Z, Fei X, Tian Y, Zhou G, Hu Y, Wang S, Shi H. The role of TolA, TolB, and TolR in cell morphology, OMVs production, and virulence of Salmonella Choleraesuis. AMB Express. 2022 Jan 25; 12(1): 5. （IF: 3.5，中科院三区）

7. Bo-Shun Z, Li LJ, Qian Z, Zhen W, Peng Y, Guo-Dong Z, Wen-Jian S, Xue-Fei C, Jiang S, Zhi-Jing X. Co-infection of H9N2 influenza virus and Pseudomonas aeruginosa contributes to the development of hemorrhagic pneumonia in mink. Veterinary Microbiology. 2020 Jan; 240: 108542. （IF: 2.4，中科院二区）